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Drugs in Use - AIDS

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The first type is called nucleoside analog reverse transcriptase (say "trans-krip-tase") inhibitors, or "nukes."

When HIV infects a healthy cell, it needs the cell's DNA, or genetic instructions, to build copies of itself. These drugs act by blocking the HIV's ability to copy a cell's DNA. Without complete DNA, HIV can't make new virus copies. These medicines include the following:

Zidovudine, also known as AZT Didanosine, also known as ddI Zalcitabine, also known as ddC Lamivudine, also known as 3TC Stavudine, also known as d4T Abacavir, also known as ABO


The second type of medicine is called a non-nucleoside reverse transcriptase inhibitor. These drugs also prevent HIV from using a healthy cell's DNA to make copies of itself, but in a slightly different way. This group includes the following medicines:

  • Delavirdine
  • Nevirapine
  • Efavirenz, also known as EFV

The third type of medicine is called protease (say "pro-tee-ase") inhibitors. These medicines work by preventing infected cells from releasing HIV into the body. This group includes the following medicines:

  • Saquinavir
  • Indinavir
  • Nelfinavir
  • Ritonavir
  • Amprenavir
The fourth type of medicine is called a fusion inhibitor, such as enfuvirtide. This medicine works by preventing the entry of the HIV virus into your body's healthy cells.

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